One complaint regarding this post will be that all of these trials are focused on drugs/gene therapies/etc. Excellent services from the doctors and nurses of the gastroenterology team . Nature, 2020; 582 (7813): ... (2020, June 25). In 2017, researchers in Nebraska completed a clinical trial assessing this immunomodulator drug in Parkinson’s, and they reported interesting results (Click here to read a SoPD post about this). You have to manage the symptoms. https://endpts.com/stem-cell-pioneer-jeanne-loring-tosses-hat-into-quickening-parkinsons-race/ And there is evidence for involvement of RIPK1 in Parkinson’s (Example; also see this review). (The Cure Parkinson’s Trust was a supporter of the Bristol GDNF study). Specifically, the researchers will be transplanting human parthenogenetic stem cells-derived neural stem cells (hpNSC). It will be interesting to see the results of that trial in 2020. The following list of clinical trials is labelled as “Neuroprotective approach: Additionals” as they could not be better grouped. And this trial is interesting given the announcement in late 2018 of positive results for an open label Phase II clinical trial of EPI-589 in motor neurone disease/ALS. Yumanity have recently been Phase I clinically testing their first drug, YTX-7739, in 48 healthy individuals (Click here to read more about this trial). If you know of a clinical trial that deserves a mention – please contact me. In addition, this may vary between individuals. Pain is an under-reported but prevalent symptom in Parkinson’s Disease (PD), impacting patients’ quality of life. And ideally, the cells should remain localised to the putamen, so that they are not producing dopamine in areas of the brain where it is not desired (possibly leading to side effects). Now you may recall that we mentioned two types of immunotherapy above – passive and active. Radotinib is currently in phase III testing for chronic myeloid leukemia (Click here to learn more about that trial). In addition to these inflammasome targeting approaches, there are other anti-inflammatory treatments being clinically tested. All of the material on this website is licensed under a If we enter a clinical trial with any expectation (as a participant or observer), we are by definition biased. Share. A direct approach in halting Parkinson’s, however, requires a fundamental understanding of how the condition is actually progressing. Another new entrant to the GLP-1R agonist group is Peptron. The Phase I ResTorbio clinical study is being conducted in New Zealand, and the trial is scheduled to finish in 2020 (Click here to read more about this trial and click here to read a SoPD post on this trial). Your arms may not swing when you walk. In addition, what is not apparent from a static view like this post is that the landscape is always changing – so quickly in fact that I know within a few days of publishing this post, there will be new announcements further changing that landscape. That is interesting. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. The clinical trials we have discussed above is passive immunotherapy. The ingredients I buy online are all endogenous and target pathways you outline above. And they are clinically trialing a vaccine treatment called ‘AFFITOPE® PD01A’ (Click here to read a previous SoPD post on this topic). Reduces rigidity Both of these studies are not expected to report any results in 2020 (beyond an announcements of Part 1 completions for both studies). It will be a multi-modal approach designed for each individual’s needs. TORC1 is a master regulator of autophagy, and by inhibiting it, the waste disposal system of a cell is boosted. A valiant effort , Simon . In 2020, a clinical trial of a drug called ANAVEX2-73 is scheduled to finish. This study is scheduled to finish in late 2021. Like I said in the post, the landscape is always changing. I hope all is well. OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING REGENERATIVE THERAPIES: In the summer of 2019, the pharmaceutical company Bayer acquired a biotech company called BlueRock Therapeutics (Click here to read a SoPD post on this). The company is conducting a follow up open-label safety study of their approach which is starting in 2020 (Click here to read more about this trial). Another experimental drug, called ENT-01, is currently being clinically tested a company called Enterin Inc. And until we have developed methods that can identify Parkinson’s long before the motor features appear (which would require only a disease halting treatment), some form of cell replacement therapy is required to introduce new cells to take up lost function. Stem cells from people with Parkinson’s can be used to better understand how changes in DNA can affect dopamine-producing nerve cells. More than 6 million individuals worldwide have Parkinson disease. And the fourth on-going stem cell-based cell transplantation clinical trial is the ‘induced pluripotent stem’ (or IPS) cell study being conducted in Kyoto, Japan (Click here to read a SoPD post on this topic). We recommend a combination of several treatments that all work on the disease in a verity of beneficial ways. This was a Phase I open label clinical study testing whether young plasma infusions could be safely used on 15 people with Parkinson’s. Interestingly, Posiphen has been reported to suppress the translation of both Alzheimer’s-associated amyloid precursor protein and alpha synuclein (Click here to read more about this). This means that the actually benefits of the transplantation technique will not be apparent for some time (2-3 years on average). A biotech company called E-Scape Bio is also developing a LRRK2 inhibitor program (Click here to read more about this). The body’s immune system can be encouraged to develop its own antibodies that target the toxic form of alpha synuclein (using, Researchers can design antibodies themselves that specifically target the toxic form of alpha synuclein (while leaving the normal version of the protein alone), and then inject those antibodies into the body (. They activate autophagy pathways that break down the aggregates. Neuroprotective approach: Neurotrophic factors. Simon, Also are you aware of any synuclein knock down strategies like an ASO or an RNA interference molecule for sporadic PD? When dopamine levels decrease, it causes abnormal brain activity, leading to symptoms of Parkinsons Disease. Change ). That's because Parkinson's is a brain disease, and not only a disease of dopamine loss, Beck explained. It too is scheduled to finish in late 2020. FAF1 is a protein involved with cell death, so by inhibiting/blocking it the researchers are investigating whether this could be beneficial in Parkinson’s. Obviously, where 2020 will actually end is unpredictable, but an outline of what is scheduled over the next year will hopefully provide us with a useful resource for better managing expectations. Feb. 27 (UPI) --Researchers have developed a new drug that could correct damage to the brain caused by Parkinson's disease and lead to improvement … The loss of … OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING THE INFLAMMASOME: Another biotech company focused on the inflammasome is IFM Therapeutics. Before we finish (yes, there is still more! One of the preclinical programs was a brain-penetrant molecule which is being developed for targetting neurodegenerative conditions like Alzheimer’s and Parkinson’s (Source). But the researchers then conducted a drug screen and identified a small molecule that promotes Miro1 degradation, and they found that this drug could rescue mulitple Parkinson’s models (Click here to read a previous SoPD post on the topic). d Dundee Edinburgh Parkinson’s Research Initiative Symposium on the 20th March. New Hope for Parkinson's Disease Cure as Treatment Enters Human Trials. OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING ADDITIONALS: In 2020, we will be hoping to see news from the Parkinson’s UK’s virtual biotech firm called Keapstone Therapeutics. No disease-modifying pharmacologic treatments are available. Although the trials are inevitably of a jam tomorrow nature I am reassured that my DIY “Amazon regime” might be on the right track of slowiing progression ( of iPD in a 74 yrs male). There are no cell therapy approaches for Parkinson’s that have been approved by any medical regulators. We will hopefully hear the results of this study in 2020. Irish drug that could cure Parkinson’s Disease sold for $446 million In one of the largest deals in Irish biotech history, Inflazome, based out of Trinity, has been sold. Parkinson’s is a progressive neurodegenerative condition. This also is significant to reduce the speed of further advance of the illness. I am not going to repeat that intro here, but that the same message applies as we look ahead to what 2020 holds. An extension of that study is now being conducted, with all of the participants receiving monthly infusions of either mid- or high-dose of CDNF for a further 6 months (Click here to read more about that follow-up study). It is the combination of these two treatments, working synergistically, that provides such remarkable results. One inflammation-related biotech company that we are watching in 2020 is Inmune Bio. Following evidence suggesting beneficial effects in models of Parkinson’s and a small open label Phase I pilot study (Click here to read more about this), two larger double-blind clinical trials were initiated: PD Nilotinib and NiloPD. This can be done either directly or indirectly. This company is developing Stearoyl CoA desaturase inhibitors – these are a class of drugs that have been reported in preclinical research to reduce alpha synuclein-associated toxicity (Click here to read a SoPD post on this topic). The Trust is a UK registered charity which is a supporter of many of the clinical trials mentioned in this post. In addition to these two fetal cell transplantation studies, there are currently 4 ongoing stem cell-based clinical trials for Parkinson’s. Both pain and PD conditions cause cortical excitability reduction, but mental representations techniques are thought to be able to counteract it, resulting also effective in chronic pain conditions. In the case of Parkinson’s, this approach is primarily being focused on different forms of alpha synuclein. This is now my fourth “Road Ahead” and it’s nice to see the progress. Similarly, One additional autophagy-related biotech company worth watching in 2020 is, Started in early 2019, following the publication of a research report (, Another company working on GDNF is called, This biotech is developing orally delivered “. This approach generally involves boosting the waste disposal systems of the cell – in this manner, the cells can break down and dispose of excess proteins (like alpha synuclein) inside the cell before they have a chance to builds up and becomes toxic. This biotech company is focused on developing a novel class of vaccines that are fully synthetic (they call them ‘endobody vaccines‘) and can train the body to treat/prevent neurological condtions. Such cognitive problems aren’t very responsive to medications. Thus, in 2020, we here at the SoPD HQ are really hoping to get some news/updates regarding ongoing follow-ups of participants in their Phase I clinical studies, AND to hear word of the initation of a larger Phase II clinical trial – particularly because their last press release had some ambigous sentences regarding study outcomes which still need to be clarified – see the bottom of this post to read about this). magnesium One of the most common of these genes is called GBA. I apologise for any that I have left out, but I am primarily focusing on those starting or completing in 2020. without much difficulty The first of them is being conducted in Israel and involves 100 participants who have been evaluated for 6 months in a open label fashion (Click here to read more about this trial). “They say I … Formerly called NeuroPhage Pharmaceuticals, Proclara is clinically testing NPT 088 which can apparently break down any aggregated protein (beta amyloid, Tau, alpha synuclein, etc). Parkinsons Disease Cure – Parkinson’s Disease Overview & Treatment For Pd Motor Complications Publié par James Spencer 10 mai 2020 Publié dans Videos Étiquettes : Youtube Watch on Youtube here: Parkinsons Disease Cure – Parkinson’s Disease Overview & Treatment For Pd Motor Complications Change ), You are commenting using your Facebook account. The first is the PASADENA study. Gene therapy involves treating medical conditions with DNA rather than drugs. This causes abnormal brain activity and impairs movement along with other PD symptoms. In addition, I would like to thank Parkinson’s advocates, a novel class of vaccines that are fully synthetic (they call them ‘, But in late 2019, the Pharma company Biogen reported that one of their huge Phase III clinical trials did have a positive outcome and they are now petitioning the US FDA for market authorisation for their treatment, aducanumab (, Proteolysis targeting chimera (or PROTAC) technology is a system of degrading intracellular proteins which Arvinas is now clinically testing (Phase I testing of two PROTACs, ARV-110 and ARV-471, suggests they are safe and well tolerated (. This study (called the SKY study) recruited 140 people with early Parkinson’s and treated them twice-daily for 9 months with Deferiprone (one of 4 different doses) or a placebo drug (Click here to read more about the details of this study). 47a Eleftherias Avenue PD Nilotinib, was conducted at Georgetown University in Washington DC (Click here for the more details about this study), and in late 2019 the investigators reported that the drug was safe at lower doses, but “no significant differences were seen in motor and nonmotor outcomes between the nilotinib groups and the placebo group” (Click here to read more about this). Doctors may recommend regular follow-up appointments with neurologists trained in movement disorders to evaluate your condition and symptoms over time and diagnose Parkinsons Disease. This situation has led a growing number of biotech companies to develop small molecules that can enter and target alpha synuclein inside of cells. We are looking forward to seeing the results of this study published early in 2020. A future treatment for Parkinson’s? Your doctor may suggest you work with a physical therapist to learn an exercise program that works for you. We will be hosting the 2020 Parkinson’s UK Research Conference as an entirely online, CPD accredited, meeting. It is a Phase II study that will recruit 60 participants and follow them for 18 months (Click here to read more about this study). While some of the information discussed in this post may cause concern, please speak with your medical physician before attempting any change in an existing treatment regime. Scientists and doctors are working together to find a treatment or prevention technique. This additional treatment involves taking drugs that suppress the immune system’s ability to defend the body from foreign agents. Another biotech firm developing a small molecule to target alpha synuclein is NeuaroPore Therapies. OTHER DEVELOPMENTS TO WATCH FOR IN 2020 REGARDING GDNF: Another company working on GDNF is called Genecode. At the start of year two, members of the placebo group will switch to receive BIIB054 treatment as well. About HPA. Part 1 of the Pasadena study was scheduled to complete in December 2019, with Part 2 finishing in February 2021. Poseidonia Healthcare Another GBA-related approach involves a drug called Venglustat (formerly known as GZ/SAR402671 & Ibiglustat) which is being conducted by the biotech company Sanofi Genzyme. EDITOR’S NOTE: The information provided by the SoPD website is for information and educational purposes only. Massage. (The Cure Parkinson’s Trust is a supporter of the AZA-PD study). Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. The drug is a Sigma-1 agonist (Click here to read a review on Sigma-1 biology) and it is being developed by the biotech company Anavex. In addition to those clinically tested assets, Cerevel have also quietly added ‘LRRK2 inhibitor’ to their preclinical ‘lead development’ area of research (Click here to read more about this). They are currently conducting a Phase I safety/tolerability trial of UB-312 in healthy volunteers and in participants with Parkinson’s. In 2020, we will hopefully hear news about the results. If so there is no cure for this disease. WOW! Researchers have targeted this protein as a means of slowing/halting Parkinson’s. The study is scheduled to finish in 2021 (click here to read more about this study). In addition, GSK initiated a LRRK2 observation clinical study at King’s College in London (Click here to read more about this). For those interested in exercise, there are a lot of clinical trials that have just registered or recruiting (78 at the time of writing) which could be explored (Click here to read more about these). 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